Which of the following correctly handles closing a file?

The correct option for handling the closure of a file is achieved through the use of the method file.close(). In Python, this method is an integral part of file handling and is used to properly terminate the session with the file after all operations are complete. This ensures that all data is written out to the storage and that system resources are freed up. When you invoke file.close(), it effectively signals to the operating system that you're done working with that file, preventing potential data loss or corruption.

The other choices fail to represent the correct syntax or method for closing files in a typical programming context. For instance, simply using close(file) lacks the necessary context as it does not conform to the defined function or method associated with a file object. Similarly, file.end() is not a recognized method in common file handling frameworks, and while close(file.handle) implies an association with a file handle, it is not the proper approach to close the file associated with a file object. Thus, file.close() is the appropriate and standard way to ensure proper cleanup of file resources.